对人类微生物组的大规模生物合成分析揭示了多样化的保护性核糖体
Jian Zhang1, Dengwei Zhang1, Yi Xu2
1Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Nature communications
|March 29, 2025
概括
人的肠道微生物产生新的生物活性化合物,称为核糖体合成和翻译后修饰 (RiPPs). 这些RiPP显示出开发新疗法来对抗疾病和保持肠道健康的潜力.
科学领域:
- 微生物学 微生物学
- 生物化学 生化学
- 基因组学就是基因组学.
背景情况:
- 人类微生物组产生各种各样的代谢物,影响宿主健康.
- 核糖体合成和翻译后改性 (RiPPs) 是一种多功能生物活性化合物类别,具有未经探索的化学景观.
- 了解RiPP对于利用其治疗潜力至关重要.
研究的目的:
- 在与人类相关的微生物组中进行RiPPs的大规模生物合成分析.
- 识别新型RiPP并调查它们的分布和潜在的健康影响.
- 在临床前模型中证明RiPPs,特别是自诱导 (AIPs) 的治疗潜力.
主要方法:
- 对306,481个微生物基因组进行了大规模生物合成分析.
- 大数据提供了分析,以将RiPP家族与疾病相关联.
- 合成生物信息自然产品 (syn-BNP) 方法的应用.
- 九种自诱导 (AIP) 的化学合成和体外/体外测试.
主要成果:
- 发现了广泛的新型RiPPs,在肠道和口腔微生物组中丰富.
- 识别了众多RiPP家族与各种疾病之间的反向关系,表明有保护性的健康影响.
- 证明五种合成的AIPs抑制了病原体中的生物膜形成.
- 证据表明,两种AIP可以调节肠道微生物群落,并在炎症性肠病小鼠模型中减少有害物种.
结论:
- 人类微生物RiPPs代表了一个巨大的,未被充分探索的资源,具有显著的治疗潜力.
- RiPPs可以调节微生物群落,并可能在人类健康中发挥保护作用.
- 以RiPP为基础的治疗药物的有针对性的开发,如AIP,对治疗疾病和保持健康具有前景.
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