周围血液基因细胞和不同年龄组的带鼻息肉的慢性鼻炎之间的相关性
Lingling Xu1,2
1Department of Otorhinolaryngology Head and Neck Surgery, Fuzhou University Affiliated Provincial Hospital, Fuzhou, China. 15750843249@163.com.
概括
血基细胞计数可能表明慢性鼻炎与鼻息肉 (CRSwNP) 中的炎症严重程度. 建议进一步研究儿科CRSwNP的长期结果.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 带鼻息肉的慢性鼻炎 (CRSwNP) 影响到4%的人口,并显著影响生活质量.
- 尽管取得了进展,但CRSwNP仍然难以治愈,需要进一步研究其潜在的炎症机制.
研究的目的:
- 评估血基细胞作为CRSwNP中的炎症标志物的作用.
- 调查儿童,成人和老年CRSwNP患者群体炎症细胞计数的差异.
主要方法:
- 对接受内镜外科手术 (ESS) 的316名CRSwNP患者的回顾性分析.
- 患者被分为三个年龄组:儿科 (≤18岁),成人 (19-60岁) 和老年人 (≥61岁).
- 分析了血细胞计数 (基细胞,淋巴细胞,单细胞,乙细胞,白血细胞) 和隆德-麦凯 (LM) 评分.
主要成果:
- 血基细胞,淋巴细胞和单细胞计数,以及LM得分,在年龄组之间显示出显著的差异,特别是在儿科和成人/老年患者队列之间.
- 两组白血细胞 (WBC) 或乙氨基酸细胞数量没有显著差异.
- 斯皮尔曼相关性分析显示,血基细胞数量与乙素细胞,白细胞,淋巴细胞,单细胞和LM得分之间存在正相关性.
结论:
- 血基细胞计数可以作为CRSwNP患者炎症严重程度的有价值指标.
- 这些发现表明,在CRSwNP中,不同年龄组的血基细胞的作用是异质的.
- 对儿科CRSwNP患者的长期随访对于了解疾病进展和管理至关重要.
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