对于复发性或耐火性多发性骨髓瘤的卡菲尔佐米布处方模式和结果:现实世界的分析
Sharlene Dong1, Rahul Banerjee2, Adeel M Khan1
1Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center, Dallas, TX, USA.
Blood cancer journal
|March 29, 2025
概括
这项研究没有发现复发性/耐药性多发性骨髓瘤患者的结局有显著差异,这些患者接受了不同的卡菲尔佐米布剂量表. 每周服用一次56mg/m2的卡菲尔佐米布可能提供最佳的疗效与安全平衡.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 卡菲尔佐米布广泛用于复发性/耐药性多发性骨髓瘤 (RRMM).
- 卡菲尔佐米布的最佳剂量和时间表尚不清楚.
- 目前的处方模式有很大的差异.
研究的目的:
- 在RRMM中评估与不同卡菲尔佐米布剂量方案相关的结果.
- 为了评估随着时间的推移,卡菲尔佐米布的处方模式的趋势.
- 为了比较各种carfilzomib计划的疗效和安全性概况.
主要方法:
- 美国大型电子健康记录数据库的回顾性分析.
- 包括486名用卡菲尔佐米布治疗的RRMM患者.
- 三种剂量模式的比较:每周一次56 mg/m2 (K56-1x),每周两次56 mg/m2 (K56-2x) 和每周一次70 mg/m2 (K70-1x).
主要成果:
- 在2016年至2023年期间,每周一次的卡菲尔佐米布 (carfilzomib) 剂量变得更加普遍.
- 在这三个组中,无进展生存时间的中位数没有显著差异 (p=0.46).
- 心力衰竭率很低 (<5%),在所有队列中都是可比的.
结论:
- 与每周一次的计划相比,每周两次的卡菲尔佐米布似乎没有改善RRMM的结果.
- 卡菲尔佐米布56 mg/m2每周一次 (K56-1x) 可能代表一个最佳的治疗方案.
- K56-1x提供了有效性,安全性和减少治疗负担的有利平衡.
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