尿路草甘与全因和特定原因死亡率之间的关系:一项前性研究
Yi Chen1, Zhijian Wu1, Meng Li2
1Department of Cardiology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, China.
Scientific reports
|March 29, 2025
概括
尿道草甘 (GLY) 含量较高与成人全因死亡率的增加有关. 这种关联受性别的影响,也注意到对癌症死亡率的潜在影响,特别是在没有高血压的个体中.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 草甘 (GLY) 是一种广泛使用的除草剂,在粮食作物中越来越多地检测到.
- 高水平的GLY残留物对人类健康和食品安全构成风险.
- 了解GLY对死亡率的影响对于公共卫生至关重要.
研究的目的:
- 调查尿液GLY水平与美国成年人死亡率之间的关联.
- 确定影响GLY暴露和死亡结果之间的关系的因素.
- 探索潜在的性别和高血压与GLY和死亡率的相互作用.
主要方法:
- 分析了4740名成年人的国家健康和营养检查调查 (NHANES) 数据.
- 利用平滑曲线配合,通用总和和逻辑回归模型.
- 进行了子组分析,以检查性别和高血压等修改因素.
主要成果:
- 在尿路GLY和全因死亡率之间观察到正相关性.
- 每增加1ng/ml的尿液GLY与40%增加的全因死亡风险有关.
- 性别显著改变了GLY-死亡率的关联,高血压改变了GLY-癌症死亡率的联系.
结论:
- 尿液中草甘度较高与全因死亡率的增加有关.
- 性别在草甘暴露和死亡率之间的关联中起着重要作用.
- 在没有高血压的个体中,草甘可能会不成比例地影响癌症死亡率.
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