象限不对称性变化 视网膜深层毛细管退化 在病态近视症中
Yilei Shao1,2,3, Meixiao Shen1,2,3, Fan Lu1,3
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Journal of translational medicine
|March 29, 2025
概括
病态近视与斑点视网膜微血管密度的改变有关,特别是视网膜深层毛细血管 (DRCP) 中象限不对称性 (QA) 的增加. 下面斑点中DRCP密度下降显著增加了病态近视风险.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 视网膜血管疾病 视网膜血管疾病
背景情况:
- 黄斑视网膜微血管密度及其象限不对称性 (QA) 对于理解近视至关重要.
- 病态近视是一种严重的近视,可能会导致视力丧失.
研究的目的:
- 为了量化象限不对称性 (QA) 在斑点视网膜微血管密度的改变.
- 确定这些质量保证改变对病态近视发展的影响.
主要方法:
- 光学连贯断层扫描血管学 (OCTA) 用于分析表面和深视网膜毛细血管 (SRCP和DRCP) 中的黄斑视网膜微血管密度.
- 通过比较四个黄斑子场的微血管密度来计算QA.
- 进行了统计分析,包括多变量二进制逻辑回归,以评估QA与病态近视之间的关联.
主要成果:
- 与简单的高近视和对照组相比,病态近视显示出较低的SRCP和DRCP密度.
- 在病理性近视方面观察到SRCP和DRCP密度的更高QA.
- 增加DRCP密度的QA显著与病态近视发生相关 (OR=2.000,P=0.035).
- 较低的黄斑子场DRCP密度下降是一个显著的风险因素 (OR=0.435,P=0.030).
结论:
- 病态近视与黄斑视网膜微血管密度QA的显著变化有关.
- 增加DRCP密度的QA和降低DRCP密度在下面的斑点是关键指标与病态近视相关.
相关概念视频
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...
Focusing of Light in the Eye
Light rays enter the eye through the cornea, a transparent dome-shaped tissue that is the eye's outermost layer. The cornea bends or refracts, light rays traveling to the pupil. The shape of the cornea determines how much of the light is bent and whether the image will be focused correctly on the retina at the back of the eye. Once the light has passed through both refraction layers, it converges into a single focal point onto a small area. This is where photoreceptors start transforming...
Photoreceptors and Visual Pathways
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...
Diabetic Retinopathy
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...


