将腰围与体重指数对与肥胖有关的癌症风险进行比较:一项汇集的瑞典研究
Ming Sun1, Christel Häggström2, Marisa Da Silva1,3
1Department of Translational Medicine, Lund University, Malmö, Sweden.
Journal of the National Cancer Institute
|March 29, 2025
概括
腰围 (WC) 是男性肥胖相关癌症的更强的预测因素,而不是身体质量指数 (BMI). WC提供了BMI以外的其他癌症风险信息,特别是对于男性.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 总体脂肪 (BMI) 是已知的癌症风险因素.
- 腹部脂肪 (WC) 可能提供不同的风险见解.
- 这项研究将WC和BMI与肥胖有关的癌症风险进行比较.
研究的目的:
- 为了比较腰围 (WC) 和体重指数 (BMI) 作为肥胖相关癌症的风险因素.
- 为了确定WC是否提供了BMI以外的其他癌症风险信息.
- 调查这些关联中的性别特异性差异.
主要方法:
- 对一个大规模的瑞典队列 (339,190人) 的分析,包括BMI和WC数据 (1981-2019).
- 使用考克斯回归来计算WC和BMI的危险比率 (HR).
- 使用回归稀释比率和WC残留物以调整变异性并评估额外的风险信息.
主要成果:
- WC 的 1-SD 增加与男性的25%更高的与肥胖有关的癌症风险有关,而BMI 的风险为19%.
- 在女性中,WC (13%的增加) 和BMI (13%的增加) 的关联是相似的.
- 卫生间残留物与男性的癌症风险的关联比女性更强,表明了额外的预测价值.
结论:
- 腰围 (WC) 是男性肥胖相关癌症的比BMI更强大的危险因素.
- 除了BMI之外,WC还提供了其他癌症风险信息,尤其是男性.
- 从WC获得的额外风险信息在女性中不那么明显.
相关概念视频
Cancer Prevention
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Comparing the Survival Analysis of Two or More Groups
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and Cox...
Cancer Survival Analysis
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Hazard Ratio
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
For example, in a clinical trial evaluating a...


