黑人和白人成年人的细胞粘附分子和事件高血压:REGARDS研究
Tyler Harkness1, Katherine Wilkinson2, Ying K Loo3
1Boston Medical Center, Boston, Massachusetts.
Journal of hypertension
|March 29, 2025
概括
炎症生物标志物E-selectin和ICAM-1显示与新的高血压病例有关,特别是在白人成年人中. 对修改E-selectin的进一步研究可能有助于预防高血压的发展.
科学领域:
- 心血管疾病流行病学
- 炎症和免疫学 炎症和免疫学
- 高血压研究 高血压研究
背景情况:
- 由C-反应蛋白表示的炎症与高血压风险增加有关.
- 细胞粘附分子如E-selectin,ICAM-1和VCAM-1在炎症中起作用,但它们与发生性高血压的关联尚不清楚.
研究的目的:
- 调查E-选择素,ICAM-1和VCAM-1的基线水平与发生性高血压的风险之间的关联.
- 探索美国成年人之间这些关联的潜在种族差异.
主要方法:
- 该研究使用了来自REGARDS队列的1879名非高血压参与者 (年龄≥45岁) 的数据,随访时间中位数为9年.
- 修改Poisson回归被用于估计基线E-selectin,ICAM-1和VCAM-1的三位数中发生高血压的相对风险 (RR).
- 已有高血压或在基线缺乏生物标志物数据的参与者被排除在外.
主要成果:
- 在随访期间,36%的参与者患上高血压.
- 较高的E-选择素水平与白人成年人发生高血压的风险增加有关 (RR 1.27;95% CI 1.04-1.44,在最小调整的模型中比较三位数3与1).
- 在未调整的模型中,ICAM-1与更高的高血压风险有关,而在白人参与者中,VCAM-1水平更高.
结论:
- 在一些模型中,E-selectin与白人成年人发生的高血压有关,而ICAM-1在白人和黑人成年人中都显示了相关性.
- 这些发现表明,E-selectin和ICAM-1可能是高血压风险的相关生物标志物.
- 准E-selectin修饰可能是减少高血压发展的潜在策略.
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