胎盘的综合转录基因和代谢分析在德克萨米他诱导的裂口口模型中的胎盘
Lanling Lin1, Mianxing Wei1, Xiao Luo1
1State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
Birth defects research
|March 29, 2025
概括
孕产妇暴露于皮质类固醇,如德甲,可以通过诱导胎盘损伤引起口腔裂. 这项研究在子模型中发现了与口腔裂形成有关的显著的胎盘病理和代谢障碍.
科学领域:
- 发展生物学 发展生物学
- 生殖医学 生殖医学
- 毒理学 毒理学 毒理学
背景情况:
- 口腔裂是一种先天性疾病,受遗传和环境因素的影响.
- 胎盘在裂病原性中的作用,特别是在环境暴露后,尚不清楚.
- 母亲使用皮质类固醇是先天性形的已知危险因素.
研究的目的:
- 为了研究胎盘转录和代谢学变化,以应对母亲的德克萨米他暴露.
- 使用子模型探索胎盘异常和口腔裂纹形成之间的关联.
- 为了阐明胎盘对皮质类固醇诱导的口腔裂的贡献.
主要方法:
- 使用德克萨米他诱导的裂口的子模型.
- 在胎盘和羊水样本上进行非目标代谢和转录.
- 对胎盘组织进行了基因病理学检查.
主要成果:
- 裂口口腔组显示出显著的胎盘病理:纤维化,化和亡.
- 转录组分析显示,有4744个不同表达的基因与激素信号传递,血管发育和炎症有关.
- 代谢分析发现了尿素循环,酸盐代谢和尼古丁酸盐/尼古丁胺胺代谢的破坏,尿素循环的改变是显著的.
结论:
- 在这个模型中,胎盘结构和功能异常与口腔裂形成密切相关.
- 这些发现表明,胎盘在皮质类固醇诱导的 palatal裂的发病过程中起着重要的作用.
- 提供了对胎盘机制的新见解,这些机制是先天性形的基础.
相关概念视频
02:59Animal Mitochondrial Genetics
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
02:30Genomic Imprinting and Inheritance
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...