相关实验视频

Updated: May 8, 2025

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

病与无性贫血的罕见关联

Tatiana Moreira¹, Diana Simões¹, Fátima Ferreira²

¹Department of Pediatrics, Centro Hospitalar Universitário de São João, Porto, Portugal.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society

|March 29, 2025

概括

乳病 (CD) 是儿童无塑性贫血 (AA) 的罕见原因. 早期诊断和无质饮食 (GFD) 可以导致这种双重诊断的儿科患者显著恢复.

科学领域:

儿科胃肠病学儿科胃肠病学
血液学血液学血液学
免疫学免疫学免疫学

背景情况:

乳病 (CD) 是一种免疫媒介疾病,在遗传敏感的个体中由质引发.
无质性贫血 (AA) 是一种罕见但严重的疾病,其特点是骨髓衰竭.
罕见地报告了CD和AA的同时发生,特别是在儿童群体中.

研究的目的:

报告一个罕见的儿科病例,同时患有乳病和无质性贫血.
突出在这种情况下的诊断挑战和治疗结果.
强调在患有无法解释的血液学异常的儿童中考虑CD查的重要性.

主要方法:

一个4岁男孩的病例报告呈现了腹,喘息和体重减轻的症状.
实验室评估显示,细胞衰减,严重贫血,中性质衰竭,以及抗组织转质胺酶IgG抗体 (anti-tTG IgG) 的升高.
骨髓活检证实了无形成症,上消化内镜诊断了CD;治疗涉及无质饮食 (GFD).

主要成果:

患者在启动GFD后显示出临床和血清学上的改善,细胞衰减和贫血的解决.
抗tTG IgG水平下降,但仍然为正值,表明部分遵守GFD.
这是CD-AA协会报告的第八个儿科病例.

结论:

虽然很少见,但乳病和无质性贫血之间的关联值得在儿科血液学中考虑.
在出现不明原因的血液学异常,包括无塑性贫血的儿童中,应对乳病进行查.
无质饮食干预可以在患有这两种疾病的儿科患者中带来有利的结果.

关键词:

没有无形性贫血.患有乳性疾病的患者.孩子孩子孩子孩子孩子孩子没有质的无质饮食.免疫球蛋白 A 缺乏症

更多相关视频

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

A High-Throughput Electrochemiluminescence 7-Plex Assay Simultaneously Screening for Type 1 Diabetes and Multiple Autoimmune Diseases

Published on: May 29, 2020

相关概念视频

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...

Autoimmune Disorders

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...

Gastritis-II: Pathophysiology

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...

Cell-mediated Immune Responses

Cell-mediated Immune Responses

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...