儿童不良经历和慢性疾病的发展轨迹:一个人口基的纵向研究
Guilan Xie1, Jiajia Li1, Ruiqi Wang2
1Institute of Population Research, Peking University, Beijing, 100871, People's Republic of China; Oxford Institute of Population Ageing, University of Oxford, Oxford, OX2 6PR, UK.
Public health
|March 29, 2025
概括
童年不良经历 (ACE) 显著影响慢性疾病的发展. 特定的ACE及其累积数量与疾病轨迹和慢性疾病数量的增加有关,特别是在女性中.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 老年学是一门学科.
背景情况:
- 儿童不良经历 (ACE) 被认为是长期健康结果的重要决定因素.
- 对于公共卫生干预来说,了解ACEs与一生中慢性疾病的发展之间的关系至关重要.
研究的目的:
- 调查各种类型之间的关联以及ACE的累积数量和慢性疾病的发展轨迹.
- 检查ACE如何影响老龄化人口中慢性疾病的数量.
主要方法:
- 一项使用中国健康与退休长度研究 (CHARLS) 数据的队列研究包括45岁及以上的参与者.
- 评估了10种17岁前的ACE类型和14种慢性疾病类型.
- 统计分析包括潜在类轨迹建模,多项逻辑回归和概括估计方程.
主要成果:
- 在12,157名参与者中,确定了四种不同慢性疾病的发展轨迹.
- 经历身体虐待,家庭暴力,家庭精神疾病和父母死亡与不良慢性疾病轨迹的更高风险有关.
- 较多的ACE (1个或更多) 和特定的ACE (如身体虐待,家庭暴力,欺凌,家庭精神疾病和父母死亡) 与更多的慢性疾病有关,在女性中观察到更强烈的关联.
结论:
- 无论是ACE的类型还是数量,都与慢性疾病的发展轨迹和负担有显著的关联,对女性有明显的影响.
- 建议采用全生命周期的方法,强调早期,全面和综合的预防策略,以减轻ACE对慢性疾病发展的长期影响.
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