和多基物质 (PFAS) 暴露对结石风险的影响和潜在机制
Ying Cui1, Aitong Wu2, Hao Liu1
1Guangdong Food and Drug Vocational College, Guangzhou 510520, China.
Ecotoxicology and environmental safety
|March 29, 2025
概括
和多醇基物质 (PFAS) 暴露与较高的结石风险有关,特别是来自PFDA. 甘油三糖 (TyG) 和全身免疫炎症指数 (SII) 介导这种效应,涉及TNF和IL-17通路.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學專業.
- 毒理学 毒理学 毒理学
背景情况:
- 结石是一种普遍的病.
- 对和多基物质 (PFAS) 的暴露越来越令人担忧.
- PFAS与结石风险之间的联系,以及潜在的机制,仍未得到充分研究.
研究的目的:
- 调查PFAS暴露与结石风险之间的关联.
- 确定有助于结石风险的特定PFAS化合物.
- 探索潜在的调解因素和参与PFAS诱导结石形成的生物学途径.
主要方法:
- 一项采用2017-2020年国家健康和营养检查调查 (NHANES) 数据的横截面研究.
- 统计分析以评估血清PFAS水平与结石患病率之间的关系.
- 调解分析以评估甘油三糖指数 (TyG) 和全身免疫炎症指数 (SII) 的作用.
主要成果:
- PFAS暴露与结石风险增加有关.
- perfluorodecanoic 酸 (PFDA) 被确定为一个显著的贡献PFAS化合物.
- TyG指数和SII指数在PFAS-结石关系中显示出显著的调解效应.
- 建议可能涉及目标蛋白 (IL-6,TNF,ALB,IL-1B,AKT1) 和信号通路 (TNF,IL-17).
结论:
- 暴露于PFAS,特别是PFDA,会增加结石的风险.
- 甘油三糖 (TyG) 和全身免疫炎症指数 (SII) 是关键的调解者.
- TNF和IL-17信号通路可能是关键机制.
- 需要进一步的实验研究来验证这些发现并阐明机制.
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