TDP-43的播种诱导了细胞质聚合异质性和TDP-43的核功能丧失

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Updated: May 7, 2026

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
07:14

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae

Published on: February 25, 2022

Jens Rummens1, Bilal Khalil1, Günseli Yıldırım2

  • 1Laboratory of Neurophysiology in Neurodegenerative Disorders, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences, KU Leuven, Leuven Brain Institute, 3000 Leuven, Belgium.

Neuron
|March 29, 2025
PubMed
概括

研究人员从TARDNA结合蛋白43 (TDP-43) 制造出粉样状纤维,以建模神经退行性疾病病理. 人体细胞中的这种种子聚合会导致细胞质内含和TDP-43的核枯竭,模仿疾病特征.

关键词:
这就是ALS.这是一个FTD.这就是LLPS.RNA代谢的RNA代谢过程在TDP-43中使用.病理学的病理学一种类似子的种子.蛋白质聚合蛋白质的聚合物

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