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Updated: Jul 16, 2026

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depolarization
10:45

Monitoring Cleaved Caspase-3 Activity and Apoptosis of Immortalized Oligodendroglial Cells using Live-cell Imaging and Cleaveable Fluorogenic-dye Substrates Following Potassium-induced Membrane Depolarization

Published on: January 13, 2012

使用化学探针可视化细胞死亡期间calpain-1激活及其在GSDMD裂变中的作用

Natalia Horbach1, Małgorzata Kalinka1, Natalia Ćwilichowska-Puślecka1

  • 1Faculty of Chemistry, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland.

Cell chemical biology
|March 29, 2025
PubMed
概括

使用新型化学工具在活细胞中可视化Calpain-1蛋白酶活性. 这种蛋白酶被发现可以切割gasdermin D,这表明它在灭症中的作用超出了其在灭症中的已知功能.

关键词:
这就是HyCoSuLL的原因.基于活动的探测器.卡尔帕因-1 卡尔帕因-1气体皮层 D D D D D质量细胞计量质量测量中性粒细胞中性粒细胞.蛋白质酶是一种蛋白质酶.热致灭症是什么?基质特异性 基质特异性

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Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.