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相关概念视频

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
The Thyroid Gland01:23

The Thyroid Gland

The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
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Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

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相关实验视频

Updated: Jul 6, 2026

An Ex vivo Culture System to Study Thyroid Development
08:33

An Ex vivo Culture System to Study Thyroid Development

Published on: June 6, 2014

在甲状腺癌进展期间,一个空间分辨的转录组景观.

Tian Liao1, Yu Zeng2, Weibo Xu1

  • 1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Cell reports. Medicine
|March 29, 2025
PubMed
概括

甲状腺癌的进展涉及复杂的瘤微环境 (TME) 重塑. 这项研究使用空间转录学绘制了TME变化的地图,揭示了诊断和治疗至关重要的不同细胞群和相互作用.

关键词:
细胞与细胞的相互作用.单细胞转录组学 单细胞转录组学空间转录学 空间转录学甲状腺癌是一种癌症.瘤前沿地区地区.

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Last Updated: Jul 6, 2026

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Published on: June 6, 2014

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05:39

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科学领域:

  • 在瘤学瘤学.
  • 基因组学就是基因组学.
  • 细胞生物学 细胞生物学

背景情况:

  • 甲状腺癌的进展受到瘤微环境 (TME) 重塑的影响.
  • 在甲状腺癌中TME变化的空间动态仍然不太清楚.

研究的目的:

  • 在甲状腺癌的不同阶段空间地绘制TME架构,从准瘤组织到厌塑性甲状腺癌.
  • 为了确定分子和细胞异质性和关键的细胞相互作用驱动甲状腺癌的进展.

主要方法:

  • 空间转录组学和单细胞RNA测序的整合.
  • 组织样本的分析,包括甲状腺副瘤 (PT),乳头甲状腺癌 (PTC),局部晚期PTC (LPTC) 和形甲状腺癌 (ATC).

主要成果:

  • 鉴定了与不同疾病阶段相关的三个不同的甲状腺细胞元群:PT中的TG+IYG+,早期的HLA-DRB1+HLA-DRA+和晚期进展中的APOE+APOC1+.
  • 揭示了特定阶段的瘤前沿重塑和高可信度的细胞相互作用 (例如,PTC中的 COL8A1-ITHB1,LPTC中的 LAMB2-ITGB4,ATC中的 SERPINE1-PLAUR).
  • SERPINE1表达和SERPINE1+纤维细胞丰度与恶性进展和预后相关.

结论:

  • 这项研究提供了TME在甲状腺癌重塑的空间解析框架.
  • 这些发现为甲状腺癌异质性,进展机制和潜在的治疗点提供了新的见解.