评估电子尼古丁输送系统对慢性阻塞性肺病的影响:系统性审查和元分析
Ajay Malvi1, Mahalaqua Nazli Khatib2, Subbulakshmi Ganesan3
1National Institute of Pharmaceutical Education and Research, Guwahati, India.
电子尼古丁输送系统 (ENDS) 或电子烟与患慢性阻塞性肺病 (COPD) 的风险更高有关. 这一元分析证实了与ENDS使用相关的COPD风险增加,即使考虑到烟草吸烟史.
科学领域:
- 肺部医学 肺部医学
- 公共卫生 公共卫生
- 毒理学 毒理学 毒理学
背景情况:
- 电子尼古丁输送系统 (ENDS) 或电子烟越来越受欢迎,特别是在年轻人和前吸烟者中.
- 人们对ENDS的长期呼吸系统健康影响存在担忧,特别是它们与慢性阻塞性肺病 (COPD) 的联系.
- 这项研究评估了ENDS使用和COPD风险之间的关联,将烟草吸烟视为混因素.
研究的目的:
- 系统地审查和元分析ENDS使用与COPD风险之间的关系.
- 评估ENDS对呼吸系统健康的影响,控制烟草吸烟史.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science) 进行了全面的文献搜索,截至2024年9月20日.
- 包括观察性研究,研究ENDS使用与COPD风险之间的关联.
- 进行了一项随机效应元分析,并在报告时对烟草吸烟进行了调整.
主要成果:
- 在分析中包括了15项研究.
- 目前使用ENDS显示COPD风险的几率比 (OR) 为1.488 (95% CI:1.363-1.623).
- 曾经和经常使用者也表现出COPD风险增加 (OR分别为1.839和1.787).
结论:
- 这一元分析表明,ENDS使用与COPD风险增加之间存在显著的关联.
- 观察到的关联甚至在调整烟草吸烟后仍然存在.
- 需要进一步的研究来规范吸烟调整,并澄清ENDS对COPD的独立影响.
更多相关视频
09:30A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
08:39Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
相关概念视频
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
