青春期和成年期怀孕期间的压力会影响下丘脑中的基因素乙化调节器
Laiklyn A M Luther1, Samantha L Higley1, Kathleen E Morrison1
1Department of Psychology, West Virginia University, Morgantown, WV 26506, USA.
Neuroscience
|March 29, 2025
概括
女性在青春期和怀孕期间的压力会改变大脑中的表观遗传机制. 在副腹腔核 (PVN) 中降低了基因组脱乙酶 (HDAC) 活性,促进了基因组乙化,影响了应力轴调节.
科学领域:
- 神经科学是一个神经科学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 青春期期间的压力事件增加了女性的负面健康结果,特别是当与晚年怀孕相结合时.
- 以前的研究表明,结合青春期的压力和成年人怀孕会使下丘脑-垂体-上腺 (HPA) 应激轴的应激反应变得麻木.
- 下丘脑的副腹腔核 (PVN) 是一个关键的HPA轴调节器,在有风险的小鼠中显示染色质开放度增加.
研究的目的:
- 调查基因组乙化调节剂 (HAT和HDAC) 在PVN中的作用.
- 了解青春期的压力和怀孕如何相互作用,影响HPA轴.
- 描述女性压力失调背后的表观遗传机制.
主要方法:
- 在小鼠的PVN中测量了基因组乙转移酶 (HAT) 和基因组脱乙酶 (HDAC) 的活性.
- 与先前的转录和染色质可访问性数据相关联的乙化基调.
- 研究了青春期和怀孕期间压力对表观遗传修饰的影响.
主要成果:
- 在PVN中的基因组乙化基调预测了转录和染色质结果.
- 暴露于青春期压力的孕妇小鼠在PVN中表现出一种亲乙化基调.
- 这种亲乙化基调是由减少的HDAC活性驱动的.
结论:
- 乙化调节剂在孕妇,青春期压力女性的PVN染色质景观改变中发挥作用.
- 涉及激素乙化的表观遗传机制与压力反应的化有关.
- 这些发现提供了对女性特有的表观遗传易受压力相关疾病的洞察力.
相关概念视频
05:12Murine Nasal Lavage Fluid Collection without Blood Contamination
1.7K
The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...
1.7K
03:40Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
1.1K
OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
1.1K
04:35Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
880
Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.
880
08:47Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
2.9K
A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
2.9K
06:49Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
12.0K
Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...
12.0K
07:15Intranasal Administration of CNS Therapeutics to Awake Mice
61.4K
A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...
61.4K