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Shiping He1, Zhan Rong2, Yanhong Wang3
1Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, Beijing, China; State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
塔卡亚苏动脉炎 (TAK) 患者面临高心血管事件风险. 关键预测因素包括延迟诊断,ESR升高,以及特定的血管状况,从而能够更好地预测风险.
科学领域:
- 心血管医学 心血管医学
- 类风湿病学 类风湿病学
- 血管生物学 血管生物学
背景情况:
- 塔卡亚苏动脉炎 (TAK) 是一种罕见的,慢性炎症性疾病,影响大动脉,主要是大动脉及其分支.
- 心血管事件是TAK患者发病和死亡的主要原因.
- 识别风险因素和开发预测模型对于管理TAK患者至关重要.
研究的目的:
- 确定与TAK患者心血管事件相关的因素.
- 在TAK中开发和验证10年心血管事件概率的预测模型.
- 为个性化风险评估和管理策略提供一个工具.
主要方法:
- 预计将在7个中心招收702名TAK患者 (2013年7月 - 2021年3月).
- 考克斯比例危险回归分析,以确定独立的风险因素.
- 模型验证使用哈雷尔的协同指数 (C指数),布里尔得分和校准图.
主要成果:
- 心血管事件发生在13.4%的患者中,平均随访时间为67个月.
- 确定了独立的风险因素:在诊断时的晚年,诊断延迟≥3年,无脉,肺高血压,大动脉反,以及在疾病发作时红细胞沉积率 (ESR) 的升高.
- 预测模型表现出良好的表现,乐观度调整后的C指数为0.71和Brier分数为0.072.
结论:
- TAK患者有显著的心血管事件的风险.
- 年龄,诊断延迟,特定的临床/成像发现 (无脉,肺高血压,大动脉反) 和炎症标志物 (ESR) 是关键预测因素.
- 开发的预测模型和名图可以帮助估计TAK的10年心血管事件风险.
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