循环的粘膜关联不变T细胞预测急性缺血性中风的早期神经系统恶化
Ruihua Liu1, Lulu Pei2, Jiacheng Liu3
1Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Neurology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, China.
概括
在急性缺血性中风 (AIS) 患者的粘膜相关不变T细胞 (MAIT) 频率降低可能预测早期神经系统恶化 (END). 调节MAIT细胞可以为AIS提供一种新的治疗方法.
科学领域:
- 神经免疫学 神经免疫学
- 这是天生的免疫力.
- 中风研究研究中风研究
背景情况:
- 粘膜关联的不变T细胞 (MAIT) 是具有快速细胞因子 (TNF-α,IL-17) 生产特征的与生俱来的类似淋巴细胞.
- 免疫反应显著影响与中风相关的损伤.
- 在缺血性脑损伤中MAIT细胞的作用仍未得到充分研究.
研究的目的:
- 评估在急性缺血性中风 (AIS) 中循环MAIT细胞的预测值.
- 评估MAIT细胞与AIS患者早期神经系统恶化 (END) 之间的关联.
主要方法:
- 预期在中风发作72小时内招募AIS患者和健康对照组.
- END的定义是NIH中风评分在72小时内增加≥2点.
- 使用接收器运行特征 (ROC) 曲线来分析MAIT单元预测值的 END.
主要成果:
- 与对照组相比,在AIS患者中观察到更低的循环MAIT细胞频率 (OR:0.83,P=0.02).
- 在AIS患者中IL-17和TNF-α水平升高与MAIT细胞频率负相关.
- 降低MAIT细胞频率预测AIS患者的END (OR:0.74,P=0.03) 的AUC为0.641.3的患者.
结论:
- 在AIS患者中,MAIT细胞频率下降.
- 循环MAIT细胞可以作为中风后早期神经系统恶化的预测生物标志物.
- 准MAIT细胞为AIS提供了一个潜在的新疗法策略.
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