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相关概念视频

Atomic Force Microscopy01:08

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...

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相关实验视频

Updated: May 9, 2026

Atom Probe Tomography Analysis of Exsolved Mineral Phases
08:14

Atom Probe Tomography Analysis of Exsolved Mineral Phases

Published on: October 25, 2019

进步的原子探头断层扫描能够在接近原子的尺度上理解骨微观结构.

Tim M Schwarz1, Maïtena Dumont2, Victoria Garcia-Giner3

  • 1Max-Planck-Institute for Sustainable Materials, Max-Planck-Str. 1, Düsseldorf 40237, Germany.

Acta biomaterialia
|March 29, 2025
PubMed
概括

这项研究通过使用in-situ金属涂层来增强原子探头断层扫描 (APT) 用于骨分析. 这提高了样品产量和化学敏感性,使得骨的层次结构和生物矿物化过程的近原子分辨率.

关键词:
原子探头断层扫描 (Atom probe tomography) 是一种可以检测原子探头的技术.生物矿物化 生物矿物化骨结构 骨结构 骨结构人物特征的发展和发展.

更多相关视频

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
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A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

Published on: June 12, 2020

Picometer-Precision Atomic Position Tracking through Electron Microscopy
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Picometer-Precision Atomic Position Tracking through Electron Microscopy

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相关实验视频

Last Updated: May 9, 2026

Atom Probe Tomography Analysis of Exsolved Mineral Phases
08:14

Atom Probe Tomography Analysis of Exsolved Mineral Phases

Published on: October 25, 2019

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT
07:10

A Sectioning, Coring, and Image Processing Guide for High-Throughput Cortical Bone Sample Procurement and Analysis for Synchrotron Micro-CT

Published on: June 12, 2020

Picometer-Precision Atomic Position Tracking through Electron Microscopy
15:04

Picometer-Precision Atomic Position Tracking through Electron Microscopy

Published on: July 3, 2021

科学领域:

  • 生物矿物化和生物材料科学 生物矿物化和生物材料科学
  • 材料科学中的高级分析技术 材料科学中的高级分析技术
  • 纳米级结构和化学分析.

背景情况:

  • 骨结构是分层组织成有机 (原) 和无机 (酸盐) 组成部分.
  • 基本的生物矿化机制,包括微量元素的影响和矿物合物排列,仍然不太清楚.
  • 传统的原子探头断层扫描 (APT) 在骨分析中面临挑战,例如样本产量低和有机成分损失.

研究的目的:

  • 克服APT在分析骨复杂的层次结构和化学成分方面的局限性.
  • 为了提高样本产量和化学敏感性,用于纳米尺度骨分析.
  • 为了使近原子尺度的研究的生物矿物化过程在骨头.

主要方法:

  • 在聚焦离子束 (FIB) 制备过程中,对APT标本施加现场金属涂层.
  • 探索和优化测量参数,用于APT分析带有和没有涂层的骨样.
  • 从纯酸 (HAP) 和原获得的参考光谱,以帮助解读复杂的质谱.

主要成果:

  • 现场金属涂层在APT骨分析中显著改善了样品产量和化学敏感性.
  • 能够在纳米尺度上分析单个原纤维和微量元素 (如Mg,Na).
  • 完成了对整个原纤维和矿物原接口的近原子尺度分析.

结论:

  • 开发的现场金属涂层方法增强了APT用于骨结构和化学分析的能力.
  • 这种技术为了解骨的层次结构和化学异质性开辟了新的途径.
  • 为未来研究生物矿物化过程,骨疾病和生物材料开发提供了强大的工具.