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Updated: Jul 6, 2026

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
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在大型生物库中进行全基因组基因环境相互作用分析的有效和准确框架

Yuzhuo Ma1, Yanlong Zhao2,3, Ji-Feng Zhang2,3

  • 1Department of Medical Genetics, School of Basic Medical Sciences, Peking University, Beijing, China.

Nature communications
|March 29, 2025
PubMed
概括

我们介绍了SPAGxECCT,这是一个可扩展的框架,用于分析跨多种特征的基因环境相互作用. 这种方法准确计算p值,并扩展到处理大群体中人口分层和祖先特异效应.

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Large-Scale Multi-Omics Genome-Wide Association Studies (Mo-GWAS): Guidelines for Sample Preparation and Normalization

Published on: July 27, 2021

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...