在COVID后的状态下大脑连接的重组:F-FDG PET研究18
Antoine Verger1,2, Matthieu Doyen2, Sebastien Heyer1
1Department of Nuclear Medicine and Nancyclotep Imaging Platform, Université de Lorraine, CHRU Nancy, 54000, Nancy, France.
EJNMMI research
|March 29, 2025
概括
大脑成像显示COVID后病情 (PCC) 患者的代谢连接性发生变化. 低代谢网络中的这种重组表明随着时间的推移演变的功能适应.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 后COVID状态 (PCC) 与低代谢性大脑模式有关.
- 研究代谢连接性的变化对于理解PCC的神经影响至关重要.
研究的目的:
- 研究在被诊断为COVID后病情 (PCC) 的患者中代谢连接的重组.
主要方法:
- 从188名PCC患者和120名健康对照人的脑部18F-FDGPET扫描进行了回顾性分析.
- 进行了基于voxel的组比较和区域间相关性分析.
- 图形分析评估了连接效率指标.
主要成果:
- 在PCC患者中发现了三个低代谢:右前,右小脑和左小脑.
- 与对照组相比,PCC患者的代谢连接性发生了变化,特别是那些感染后延迟较长 (> 9 个月) 的患者.
- 图形分析表明PCC患者的连接效率下降.
结论:
- 在PCC患者的低代谢大脑网络内,代谢连接性发生变化.
- 这些发现表明,在COVID后的大脑中,随着时间的推移,存在持久的重组和功能适应.
更多相关视频
09:58Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
Published on: November 9, 2018
6.5K
07:28Studying Metabolic Brain Connectivity Using 2-Deoxy-2-[18F]Fluoro-D-Glucose Dynamic Positron Emission Tomography at the Single-subject Level
Published on: January 24, 2025
768
相关概念视频
Positron Emission Tomography
6.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.2K
Imaging Studies II: Positron Emission Tomography and Scintigraphy
853
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
Fundamental Principles of PET
853
Brain Imaging
1.0K
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans), magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
1.0K
