对成人和老年人肺炎的血清型分布进行系统审查
1Sanofi Pasteur, Lyon, France. fatiha.mrb@gmail.com.
BMC public health
|March 29, 2025
概括
肺炎球菌性肺炎仍然对老年人构成重大威胁. 血清型3,19A和11A是常见的原因,强调需要持续监测疫苗战略.
科学领域:
- 医学微生物学 医学微生物学
- 流行病学 流行病学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肺炎球菌性肺炎是成年人疾病和死亡的主要原因,特别是65岁以上的人.
- 了解血清型特定的流行病学对于有效的疫苗接种政策和疫苗开发至关重要.
研究的目的:
- 为了确定负责老年人群肺炎的特定肺炎球菌血清型.
主要方法:
- 对从1984年到2020年的PubMed数据库进行了系统审查.
- 纳入标准侧重于成人肺炎球菌性肺炎的研究,不包括元分析和病例报告.
- 包括在疫苗引入后发表的研究 (PPSV23和PCVs).
主要成果:
- 分析了40项研究,确定了Streptococcus pneumoniae血清型3是成年人中最常见的.
- 血清型19A和11A也经常被确定为肺炎的原因.
- 观察到非疫苗血清型的增加,表明流行病学正在演变.
结论:
- 肺炎球菌性肺炎继续对老年人造成重大负担,即使有现有的疫苗.
- 在这个人口群体中不断监测新出现的血清型对于完善疫苗接种策略至关重要.
- 2019年,肺炎球菌性肺炎在全球造成约140万例死亡,其中一半发生在70岁以上的人群中.
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