营养补充剂对神经发育障碍患者肠道微生物群的影响:系统性审查和叙事合成
Elaheh Dehghani1,2,3, Keyvan Karimi2,4, Soheil Arekhi2
1Department of Clinical Nutrition, School of Nutrition and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
BMC nutrition
|March 29, 2025
概括
营养补充剂通过改善肠道健康和减少症状,对神经发育障碍产生积极影响. 本综述强调了肠-大脑轴连接以及有针对性的微生物组调节的好处.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 神经发育障碍 (NDD) 是一种复杂的疾病,与肠-大脑轴有潜在的联系.
- 营养补充剂可能会影响NDD的胃肠道 (GI) 和行为症状.
研究的目的:
- 探索营养补充剂对NDD患者肠道微生物群和行为症状的影响.
主要方法:
- 在主要数据库 (PubMed,Scopus,Web of Science,Embase,APA PsycINFO) 和灰色文献中进行系统的文献搜索.
- 使用ROBINS-I和ROB-1工具进行偏差风险评估.
- 由于研究异质性,没有元分析的合成 (SWiM).
主要成果:
- 补充剂对胃肠道严重性指数 (GIS) 有积极影响,并减少了胃肠道症状.
- 益生菌和维生素在自闭症谱系障碍 (ASD) 中增加了有益的肠道微生物组 (GM) 并减少了有害的 (BM).
- 在Firmicutes与Bacteroidetes比率 (F/R比率) 和行为评分 (ATEC,ABC,CARS,PGI-2) 的显著变化和改善被观察到.
结论:
- 营养补充剂调节微生物组,减少异位生物,并增强NDD的肠道屏障完整性.
- 调整F/R比可以通过影响神经递质活性和神经炎症来改善胃肠道和行为症状.
- 通过肠道微生物群干预来准肠-大脑轴是NDD管理的有希望的辅助疗法.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
219
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
219
Anatomy of the Intestines
70.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
70.4K
Attention-Deficit/Hyperactivity Disorder
21
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
21


