Biofire FilmArray®脑膜炎/脑炎小组测试的临床和成本影响:系统性审查
Nastaran Rafiei1, Shradha Subedi2, Patrick Na Harris3
1Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Australia; Caboolture Hospital, Queensland, Australia.
Diagnostic microbiology and infectious disease
|March 30, 2025
概括
生物火 FilmArray® 脑膜炎/脑炎面板 (MEP) 减少了对传染性脑膜炎的阿西克洛维尔的使用. 然而,它对抗生素使用和住院的影响因机构和患者群体而异.
科学领域:
- 临床微生物学 临床微生物学
- 传染病 传染病 传染病
- 诊断技术 诊断技术 诊断技术
背景情况:
- 脑膜炎和脑炎的死亡率和后果率很高,由于常规测试的局限性,往往缺乏病因诊断.
- 生物火膜Array®脑膜炎/脑炎面板 (MEP) 是一种多重PCR诊断工具,用于传染性脑膜炎,提供快速的结果.
- 与传统方法相比,MEP有可能减少实证抗微生物药物的使用,缩短住院时间.
研究的目的:
- 系统地审查实施MEP对患者结果的影响.
- 评估在MEP实施后的阿西克洛维尔治疗持续时间,抗菌剂使用,住院时间和医疗费用变化.
主要方法:
- 对Medline和Embase数据库进行系统审查.
- 包括23项研究,主要是回顾性研究,比较MEP实施前和后的队列.
- 评估的结果包括阿西克洛维尔和抗菌药物治疗的持续时间,停留时间和医疗费用.
主要成果:
- 在75%的研究中 (平均39小时),MEP的实施减少了阿西克洛维尔的使用.
- 在44%和40%的研究中,分别观察到抗菌素使用和停留时间的减少.
- 医疗保健成本分析是可变的;一项研究显示总住院费用减少,而两项研究显示没有变化.
结论:
- MEP的实施有效地减少了对脑膜炎/脑炎进行评估的患者的阿西克洛维尔使用.
- 关于MEP对抗生素使用和停留时间的好处是不一致的.
- 结果的变化可能取决于患者群体,实施策略和可用的标准诊断测试.
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