一种物理集成的深度学习方法,用于使用PPG进行患者特定的非牛顿血粘度评估
Hyeong Jun Lee1, Young Woo Kim1, Seung Yong Shin2
1Division of Biomarkers, Imaging, and Hemodynamic Studies (BIOS), Department of Mechanical Engineering, Yonsei University, Seoul, Korea; Center for Precision Medicine Platform Based on Smart Hemo-Dynamic Index (SHDI), Seoul, Korea.
Computer methods and programs in biomedicine
|March 30, 2025
概括
这项研究使用新型人工智能模型从光聚光显微镜 (PPG) 中提取患者特异性的血液粘度. 这项创新扩大了对循环系统疾病的可穿戴健康监测.
科学领域:
- 生物医学工程 生物医学工程
- 生理测量生理测量
- 医疗保健中的人工智能
背景情况:
- 越来越多的老年人群需要先进的远程,非侵入性健康监测.
- 目前的可穿戴设备不能有效地监测循环系统.
- 非侵入性地测量血液粘度可以显著提高可穿戴健康技术.
研究的目的:
- 开发一种方法,从光电显微镜 (PPG) 数据中提取患者特定的血液粘度方程.
- 通过可穿戴设备来监测循环系统的健康状况.
- 扩大非侵入性健康监测系统的应用范围.
主要方法:
- 开发了一种混合的1D卷积神经网络-长期短期记忆 (CNN-LSTM) 架构.
- 纳入了基于物理学的约束,整合了学的原则.
- 该模型使用k-fold交叉验证进行训练,优化基于卡罗-亚苏达模型的损失函数的重量.
主要成果:
- 估计模型的整体准确度为81.1%,在生理剪切范围 (50-300s-1) 中准确度为84.0%.
- 在生理学范围中,平均绝对误差为0.67cP,处于临床粘度计容忍度 (<1cP) 之内.
- 在预测和基本真相值之间观察到强烈的线性关系 (相关系数:0.619-0.742,p < 0.0001).
结论:
- 来自PPG的血液粘度的非侵入性估计可以显著提高可穿戴医疗保健系统的诊断能力.
- 这种方法显示了针对各种循环系统疾病的潜力.
- 在生理学上相关的剪切范围中证明的准确性支持潜在的临床应用.
相关概念视频
01:29Blood Flow
Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
01:19Assessing Blood pressure using a doppler ultrasound
To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
01:10Pre-Procedural Guidelines for Assessing Blood Pressure
Accurate blood pressure assessment is crucial for diagnosing and managing various health conditions. To ensure the reliability of these measurements, healthcare professionals must adhere to standardized pre-procedural guidelines. These guidelines enhance patient safety and improve the overall quality of healthcare. The following steps are essential for obtaining accurate and consistent blood pressure readings, from using the appropriate tools to ensuring effective communication with the patient.
00:57Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
01:27Applications of Integration to Find Blood Flow
Blood flow through a cylindrical blood vessel can be mathematically described using the principles of laminar flow, a regime in which fluid moves smoothly in parallel layers. In this model, the velocity of the blood is not uniform across the cross-section of the vessel; rather, it varies with the radial distance from the center. The maximum velocity occurs along the central axis, decreasing progressively toward the vessel walls, where it reaches zero due to viscous drag.Approximating Blood...