产生的 Staphylococcus hyicus 排泄性表皮炎 ExhC:在集约猪生产中对新出现的病原体进行控制的建议
Antonio Romero-Salmoral1, Carmen Álvarez-Delgado2, Rafael A Muñoz-Jiménez3
1Department of Animal Health. Animal Health Research Group: Diagnosis and Control of Diseases (SANDYC). Unidad de Investigación Competitiva (UIC) Zoonosis y Enfermedades Emergentes ENZOEM, University of Córdoba, Córdoba, Spain.
Veterinary journal (London, England : 1997)
|March 30, 2025
概括
由Staphylococcus hyicus引起的小猪排泄性表皮炎 (EE) 疫情通过使用自身疫苗和改进农场管理得到解决. 这一战略有效地降低了小猪的发病率和死亡率.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 细菌疾病研究研究
- 猪健康 猪健康
背景情况:
- 湿疹性表皮炎 (EE) 是小猪的一种传染病,偶尔会引起严重的爆发.
- 在大型商业母猪养殖场爆发时,产生皮毒素C型 (ExhC) 的海螺杆菌被确定为致病原体.
- 疫情导致哺乳小猪的高发病率 (70%) 和死亡率 (5%).
研究的目的:
- 描述一家商业养猪场的EE疫情的诊断和控制措施.
- 评估自身疫苗接种和改进的管理实践在解决EE疫情的有效性.
主要方法:
- 诊断包括从受影响动物中分离细菌和脉冲场凝电泳 (PFGE) 来确定菌株类型.
- 控制措施包括母猪的自身疫苗接种,加强清洁和消毒协议,以及选择健康的替代动物.
- 基因分析 (PFGE) 证实了所有S. hyicus分离物的共同起源.
主要成果:
- 产生ExhC的S. hyicus被确定为严重EE爆发的原因.
- PFGE分析表明细菌分离物的单一共同来源.
- 改进的生物安全,管理和自身疫苗接种成功地将疾病和死亡率在三个月内降至零.
结论:
- 有效控制EE爆发需要准确的诊断,生物安全评估和有针对性的免疫预防.
- 自生疫苗,当与管理改进相结合时,对于解决猪群中S. hyicus诱导的EE疫情至关重要.
- 解决卫生协议的缺陷对于预防和控制生育单位的疾病爆发至关重要.
相关概念视频
01:23Hand hygiene
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
01:19Clinical Applications of Epidermal Stem Cells
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
01:18Surface Membrane Barriers
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
01:29Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
01:18Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
01:25Clinical Significance of Antibiotic Resistance
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...