作为局部和透皮药物递送研究的扩散模型的双层皮肤等价物
Runze Zhou1, Zhi Xiao1, Tianchi Lu2
1Department of Pharmaceutics, China Pharmaceutical University, Nanjing 211198, China.
Carbohydrate polymers
|March 30, 2025
概括
一种新型的双层皮肤等价物 (DSE) 模仿了真皮,用于体外透测试. 这种DSE显示类似于迷你猪皮肤的药物释放,为局部/透皮药物评估提供了一个有希望的替代方案.
科学领域:
- 生物材料科学 生物材料科学
- 皮肤研究 皮肤研究
- 药物输送系统 药物输送系统
背景情况:
- 在体外透试验 (IVPT) 对于评估局部/透皮药物输送至关重要.
- 目前的方法通常依赖于ex vivo人类或动物皮肤,这带来了伦理和可变性挑战.
- 开发可靠的皮肤等价物对于科学和工业进步至关重要.
研究的目的:
- 开发一种新的双层皮肤等价物 (DSE),复制人类皮肤的结构和功能特性.
- 评估DSE作为IVPT中的动物/人类皮肤替代品的适用性.
- 为了评估DSE的通过皮肤释放药物的行为和与ex vivo皮肤模型的相关性.
主要方法:
- 制造双层皮肤等价物 (DSE),其中包括皮肤模拟层 (糖氨酸甘油,酸盐,凝) 和表皮屏障层 (电纳米聚氨).
- 描述DSE的机械性能 (压缩模量).
- 在体外穿透测试使用DSE和小型猪皮肤对3种具有不同Log P值的模型药物进行了透测试.
主要成果:
- 开发的DSE表现出与全层人体皮肤相比的压缩模量.
- 对于所有测试的药物,DSE显示出高相关性和类似的通过皮肤释放的药物特征与小型猪皮肤.
- 对DSE的动力模型拟合结果与小型猪皮肤的皮肤非常相似,性能优于其他报告的皮肤等价物.
结论:
- 这种新型的双层皮肤等效 (DSE) 有效地模拟了真皮的屏障功能和药物透特性.
- 在体外透测试中,DSE为动物/人类皮肤提供了可靠和可重复的替代方案.
- DSE的配方可以调整以调节透阻力,从而可以模拟各种皮肤类型.
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