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荷尔蒙相关的饮食模式和绝经前乳腺癌风险
Sable N Fest1, Leslie V Farland2,3, David R Doody1
1Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, 1100 Fairview Avenue North, Seattle, WA, USA.
Breast cancer research and treatment
|March 30, 2025
概括
饮食模式显示,与绝经前激素水平的联系很弱. 某些饮食模式与更年期前乳腺癌风险增加有关,但饮食可能不是这种激素风险关系的主要驱动因素.
科学领域:
- 内分泌学 在内分泌学.
- 营养流行病学 营养流行病学
- 在瘤学瘤学.
背景情况:
- 循环性类固醇激素与绝经前乳腺癌风险有关.
- 饮食模式对绝经前激素水平的影响还不清楚.
研究的目的:
- 为了确定与绝经前激素水平相关的饮食模式.
- 调查这些饮食模式与绝经前乳腺癌风险之间的关系.
主要方法:
- 降低等级回归被用来确定与护士健康研究II (NHSII) 的一个子集中与激素水平相关的饮食模式.
- 考克斯的比例危险模型评估了与全NHSII队列的饮食模式得分相关的乳腺癌风险.
主要成果:
- 饮食模式仅解释了个体激素水平变化的2.5-4.1%.
- 与质自由雌激醇和卵泡雌激素相关的饮食模式与绝经前乳腺癌风险有积极的关联 (HRs在1.28-1.29之间).
结论:
- 饮食因素似乎对绝经前激素水平的影响有限.
- 性类固醇激素与绝经前乳腺癌风险之间的关联不太可能仅仅是饮食驱动的.
- 未来的研究应该探索其他饮食机制,如炎症,与乳腺癌风险相关.
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