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肥胖和炎症性肠病的临床特征
Roberto Mancone1, Livia Biancone2, Sara Concetta Schiavone2
1Department of Systems Medicine, Gastroenterology Unit, University "Tor Vergata" of Rome, Rome, Italy, roberto.mancone@yahoo.it.
Obesity facts
|March 30, 2025
概括
患有克罗恩病 (CD) 的超重和肥胖患者患上周疾病和生物折射性风险增加. 身体质量指数 (BMI) 显著影响CD表型和治疗反应.
科学领域:
- 胃肠病学 胃肠病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 肥胖的患病率及其与炎症性肠病 (IBD) 的特征和结果的关联仍然不清楚.
- 了解IBD患者的体重指数 (BMI) 分布对于治疗IBD患者至关重要.
研究的目的:
- 在随访期间确定IBD患者的BMI分布.
- 为了比较正常体重和超重/肥胖IBD患者之间的临床特征和疾病过程.
主要方法:
- 预期将成年IBD患者纳入定期随访.
- 在门诊期间记录BMI.
- 使用学生t测试,曼-惠特尼U测试和Chi-square测试进行比较的统计分析.
主要成果:
- 在300名IBD患者中,5.3%的患者体重不足,56.7%的患者体重正常,30.7%的患者超重,73%的患者肥胖.
- 在284名患者 (不包括体重不足) 的小组中,有40.2%的患者超重/肥胖.
- 与体重正常的同行相比,超重/肥胖的克朗氏病患者表现出较高的围疾病率 (23%vs10.1%) 和生物折射率 (23.4%vs0%).
结论:
- 在IBD随访中,体重不足患者的比例很低.
- 克罗恩病的超重和肥胖与较高的围部疾病发病率和对生物制剂的反应性降低有关.
- 体重指数 (BMI) 似乎是影响克罗恩病表型和治疗结果的重要因素.
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