深度学习量化体质组成从正子发射断层扫描/计算机断层扫描和心血管结果:一个多中心研究
Robert J H Miller1,2, Jirong Yi1, Aakash Shanbhag1,3
1Departments of Medicine (Division of Artificial Intelligence in Medicine), Imaging and Biomedical Sciences, Cedars-Sinai Medical Center, 6500 Wilshire Blvd, Suite 420, Los Angeles, CA 90048, USA.
European heart journal
|March 30, 2025
概括
对心脏PET/CT扫描的深度学习分析自动量化身体成分. 内脂肪组织 (VAT) 密度增加与死亡或心肌梗塞 (MI) 的风险增加有关.
科学领域:
- 心血管成像 - 心血管成像
- 医学图像分析 医学图像分析
- 身体组成评估评估
背景情况:
- 心脏正子发射断层扫描 (PET) /计算机断层扫描 (CT) 肌肉输液成像 (MPI) 对于诊断心脏代谢综合征至关重要.
- 在PET/CT MPI中低剂量CT扫描为身体组织组成分析提供了潜力.
- 从这些扫描中自动量化骨肌肉 (SM) 和脂肪组织是一个新兴的领域.
研究的目的:
- 从心脏PET/CT扫描中使用深度学习自动量化骨肌肉 (SM),骨和脂肪组织 (上心脏,皮下,内脏,肌间).
- 评估这些量化的身体组织与死亡或心肌梗塞 (MI) 风险的关联.
主要方法:
- 使用深度学习算法,从PET MPI扫描中对三个地点进行细分和量化SM,骨和各种脂肪组织存储 (EAT,SAT,VAT,IMAT) 的数据.
- 建立了异常组织值的性别特定值.
- 使用未调整和多变量考克斯回归模型来评估身体组成和结果 (死亡或心脏病发作) 之间的关联.
主要成果:
- 这项研究分析了10,085名患者,自动化身体组织细分快速完成 (102±4秒).
- 较高的内脏脂肪组织 (VAT) 密度与死亡或心脏病发作风险增加显著相关 (调整后危险比率 [HR] 1.24).
- 对于肌肉间脂肪组织 (IMAT),皮下脂肪组织 (SAT) 和心上脂肪组织 (EAT) 也观察到类似的关联. 患有高增值税密度和心肌流量储备减少的患者的风险明显更高 (调整HR2.49).
结论:
- 通过标准的心脏PET/CT扫描,可以快速自动推导体积体组织组成.
- 这种自动化分析提供了宝贵的定量洞察力,对萨尔科佩尼亚和心脏代谢健康.
- 这些发现突显了将身体组成分析纳入常规心脏成像检查中的潜力,以改善患者风险分层.
相关概念视频
01:29Positron Emission Tomography
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
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Troponins
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The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
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Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:21Imaging Studies for Cardiovascular System IV: CMRI
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