自闭症谱系障碍和饮食中的维生素E摄入量
Khadijeh Abbasi Mobarakeh1, Zahra Mahmoudi2, Zahra Mousavi3
1Department of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Neuropsychopharmacology reports
|March 30, 2025
概括
患有自闭症谱系障碍 (ASD) 的儿童饮食维生素E的摄入量明显低于通常发育的儿童. 增加维生素E摄入量可能会降低ASD风险,需要进一步调查.
科学领域:
- 营养神经科学 营养神经科学
- 发育儿科 发育儿科
- 自闭症研究 自闭症研究
背景情况:
- 自闭症谱系障碍 (ASD) 是一种复杂的神经发育状况,受遗传和环境因素的影响.
- 患有自闭症的人在氧化应激和抗氧化防御之间表现出不平衡.
- 饮食中抗氧化剂的具体作用,如维生素E,在ASD病因方面仍然不清楚.
研究的目的:
- 量化比较被诊断患有自闭症儿童和典型发育 (TD) 儿童之间的食维生素E摄入量.
- 调查维生素E摄入量与发展ASD的风险之间的潜在关联.
主要方法:
- 一项病例控制研究,涉及110名患有自闭症儿童 (5-15岁) 和110名TD儿童.
- 用吉利姆自闭症评分表第二版 (GARS-2) 证实了ASD诊断.
- 饮食摄入量,包括维生素E,通过食物频率问卷 (FFQ) 进行评估,并使用营养学家IV软件进行分析.
主要成果:
- 与TD儿童 (28.60 ± 10.85 mg/day) 相比,患有ASD的儿童每日饮食维生素E摄入量显著降低 (15.66 ± 12.72 mg/day).
- 调整后的分析显示,维生素E摄入量下降与ASD风险增加有关 (OR = 0.90,95% CI:0.85-0.94).
结论:
- 研究结果表明,饮食中较高的维生素E摄入量与自闭症谱系障碍的风险降低之间存在潜在联系.
- 需要进一步的研究来验证这些发现,并探索维生素E补充剂在ASD中的治疗潜力.
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