非编码RNAs:胎盘发育和怀孕成功的建筑师
Hongjuan Pan1, Baisha Ouyang1, Hui Zhang1
1Taikang Tongji (Wuhan) Hospital, Wuhan, 430050, Hubei, China.
Molecular genetics and genomics : MGG
|March 30, 2025
概括
非编码RNAs (ncRNAs) 对胎盘发育和怀孕至关重要. 研究强调了它们在并发症中的作用和潜在的诊断工具.
科学领域:
- 生殖生物学 生殖生物学
- 分子遗传学 分子遗传学
- 生物化学 生物化学
背景情况:
- 非编码RNAs (ncRNAs) 对于生物过程至关重要,包括胎盘发育,尽管缺乏蛋白质编码功能.
- 虽然研究了microRNAs (miRNAs),但其他ncRNAs如循环RNAs (circRNAs) 和长非编码RNAs (lncRNAs) 可能会对胎盘功能产生更大的影响.
- 热囊细胞及其细胞外囊泡是母胎交换的关键,使它们内的ncRNA与怀孕结果相关.
研究的目的:
- 审查目前对胎盘发育和怀孕中的ncRNAs的理解.
- 探索ncRNAs在妊娠并发症中的作用及其作为诊断和治疗点的潜力.
- 突出 ncRNAs 在胎盘生物学中超越 miRNAs 的重要性.
主要方法:
- 关于胎盘发育中的ncRNAs现有研究的文献综述.
- 对研究的分析,重点是怀孕中的microRNAs,circRNAs和lncRNAs.
- 检查细胞外囊泡在ncRNA运输和功能中的作用.
主要成果:
- ncRNAs是正常胎盘发育和怀孕成功的组成部分.
- 胎盘组织和细胞外囊中的ncRNAs的失调与怀孕并发症有关.
- ncRNAs显示出作为生物标志物用于诊断和潜在治疗与怀孕有关的疾病的前景.
结论:
- ncRNAs,特别是circRNAs和lncRNAs,在胎盘功能和怀孕中起着至关重要的作用.
- 胎盘ncRNAs的变化可以作为妊娠并发症的指标或贡献者.
- ncRNAs代表了开发产科新型诊断和治疗策略的有希望的途径.
相关概念视频
01:23Types of RNA
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
02:53Ribosomal RNA Synthesis
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
02:57piRNA - Piwi-interacting RNAs
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
02:39lncRNA - Long Non-coding RNAs
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
01:20Types of RNA
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
01:24Gonadal and Placental Hormones
The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair growth — and...