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Updated: Jul 21, 2026

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Published on: January 22, 2019

基于培的查揭示了Pyrazol-Azepinoindoles的选择性细胞静态效应

Dmitry A Skvortsov1, Irina V Zhirkina1, Daria A Ipatova1

  • 1Chemistry Department and AN Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, 119991, Russian Federation.

ChemMedChem
|March 30, 2025
PubMed
概括

研究人员使用光细胞共同培养试验 (FCCT) 确定了16种用于抗癌治疗的新型选择性细胞毒性分子. 经过优化后的pyrazole-azepinoindole衍生物23显示出显著的疗效和细胞循环停止.

关键词:
它们是抗癌的.乳腺癌模型的模型共同的文化共同的文化细胞毒性 细胞毒性肺癌模型 肺癌模型现型查 现型查 现型查

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The reaction of weakly electrophilic aryldiazonium (also called arenediazonium) salts with highly activated aromatic compounds leads to the formation of products with an —N=N— link, called an azo linkage. This reaction, presented in Figure 1, is known as diazo coupling and occurs without the loss of the nitrogen atoms of the aryldiazonium salt. Highly activated aromatic compounds such as phenols or arylamines favor the diazo coupling reaction. The coupling generally occurs at the para position.