新生儿患有赫希斯普朗格病的肠道穿孔的危险因素
Zhaozhou Liu1, Yanan Zhang1, Dayan Sun1
1Department of Neonatal Surgery, Beijing Children Hospital, Capital Medical University, National Center for Children'S Health, 56 Nanlishi Road, Beijing, 100045, China.
肠道穿孔发生在Hirschsprung病 (HD) 的新生儿的6.0%中. 早期入院,高CRP和肠道肺炎是这种严重并发症的关键危险因素.
科学领域:
- 儿科手术 儿科手术
- 新生儿医学 新生儿医学
- 胃肠病学 胃肠病学
背景情况:
- 赫施普朗格病 (HD) 在新生儿中具有显著的肠道穿孔风险.
- 早期识别风险因素对于及时干预和改善结果至关重要.
研究的目的:
- 在患有赫施普朗格病的患者中确定新生儿肠道穿孔的独立风险因素.
- 分析与肠道穿孔相关的临床特征,在这个脆弱的人群中.
主要方法:
- 从2007年至2024年期间诊断出HD的300名新生儿的临床数据的回顾性分析.
- 结肠穿孔的新生儿与没有结肠穿孔的新生儿之间的临床特征的比较.
- 单变量和多变量逻辑回归来确定风险因素.
主要成果:
- 在患有HD的新生儿中,肠孔发生率为6.0% (18/300).
- 确定的独立风险因素包括入院时的年龄<5天 (OR 4.709),CRP>20.5毫克/升 (OR 35.185) 和肠壁肺炎 (OR 9.667).
- 穿孔最常发生在西格结肠 (44.4%).
结论:
- 肠道穿孔是HD新生儿的重大并发症,发生在6.0%的病例中.
- 早期入院,高C反应蛋白 (CRP) 水平和肠壁肺炎与HD新生儿的肠道穿孔有很强的联系.
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