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Updated: Mar 9, 2026

Author Spotlight: Developing a Simple and Robust Hepatic Model for Pharmacological and Toxicological Applications
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Published on: October 20, 2023

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中外生理学基础的药动力学建模,以支持阿莱克提尼布的儿科剂量建议

Tamara van Donge1, Elena Guerini1, Amaury O'Jeanson2

  • 1Roche Pharma Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, Basel, Switzerland.

CPT: pharmacometrics & systems pharmacology
|March 31, 2025
PubMed
概括

这项研究开发了alectinib的儿科剂量模型,这是一种ALK+ NSCLC治疗方法. 它建议给3.5岁以下的儿童使用较低的剂量,以确保安全有效的暴露.

关键词:
阿莱克提尼布 (Alectinib) 是一种药物.PBPKK PBPK 的意思是什么意思剂量建议 剂量建议母代谢物的代谢物.儿科 儿科 儿科 儿科人口的药理动力学

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