相关实验视频

Updated: Jun 19, 2026

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis
10:03

Screening for Amyloid Aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

Published on: July 16, 2008

研究人类癌症相关蛋白质的聚合和原性质

Dustin Goncharoff1, Zhiqiang Du1, Shriram Venkatesan2

  • 1Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.

Molecular and cellular biology
|March 31, 2025
PubMed
概括

癌症研究揭示了与癌症相关的蛋白质中的类蛋白质聚合. 这种聚合可能会导致对瘤发育和进展至关重要的表观遗传变化.

关键词:
普里昂 (Prion) 是一个子.聚合方式 聚合方式 聚合方式癌症 癌症 癌症 癌症 癌症类域 (PrLD) 是一种类似子的域.酵母酵母是一种酵母.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...