在选择性PCI后使用CKMB进行心肌损伤:发生率和与长期死亡率的关联
Nina Talmor1, Claire Graves2, Sam Kozloff3
1Leon H. Charney Division of Cardiology, Department of Medicine (N.T., B.S., A.B., L.R., S.V.R., M.J.A., F.F., J.S., N.R.S.), New York University Grossman School of Medicine, NY.
Circulation. Cardiovascular interventions
|March 31, 2025
概括
穿皮冠状动脉干预 (PCI) 后心肌损伤很常见,并与长期死亡率有关. 复杂的冠状动脉解剖学预测了这种损伤,突出了风险评估的必要性.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 临床结果 临床结果
背景情况:
- 穿皮冠状动脉干预 (PCI) 后的心肌损伤与较高的死亡率有关.
- 需要进一步阐明PCI后心肌损伤的预测因子和长期预后意义.
研究的目的:
- 为了确定可选PCI后心肌损伤的预测因子.
- 评估PCI后心肌损伤对所有原因死亡率的长期预后相关性.
主要方法:
- 对10807名接受选择性PCI的成年患者进行了回顾性观察性研究.
- 心肌损伤定义为心肌皮带 (CKMB) >99%的峰值肌激酶受伤的上限.
- 用于评估预测因素和死亡风险的线性回归和Cox比例危险模型.
主要成果:
- 在PCI后的心肌损伤发生在16.8%的患者中.
- 年龄较大,病变较长,多血管PCI,严重化和血栓切除预测损伤.
- 在PCI后的心肌损伤与长期增加全因死亡率有关 (HR 1.46).
结论:
- 在PCI后升高的CKMB是常见的,并预测长期死亡率.
- 复杂的冠状动脉解剖是PCI后心肌损伤的重要预测因素.
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