T:

Ahmad Al-Jarrad1, Samhar Samer Alouch1, Yogesh Chawla1

  • 1Division of Hematology, Mayo Clinic, Rochester, MN, USA.

概括

针对BCMA和GPRC5D的T细胞参与剂在复发性/耐药性多发性髓瘤中显示出高响应率. 进一步的研究旨在提高下一代疗法的疗效和减少副作用.

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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