在儿童群体中登革热感染和SARS-CoV-2感染后的长期后果:回顾性队列研究
Liang En Wee1,2,3,4, Jue Tao Lim1,4, Janice Yu Jin Tan5
1National Centre for Infectious Diseases, Singapore.
Open forum infectious diseases
|March 31, 2025
概括
与COVID-19感染的儿童相比,登革热感染的儿童总体患急性后并发症的风险较低. 然而,登革热感染增加了儿童尾炎的风险,突显了针对性公共卫生战略的需要.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 在儿童感染SARS-CoV-2后的长期后急性后果已经得到了充分的证据.
- 儿童登革热感染后慢性症状的基于人口的研究是有限的.
- 这项研究将登革热后的多系统并发症与亚洲儿童的SARS-CoV-2进行比较.
研究的目的:
- 评估儿童登革热感染后多系统并发症的风险.
- 将这些风险与亚洲儿科人口感染SARS-CoV-2后的风险进行比较.
- 为公共卫生策略提供信息,以管理儿童的感染后病情.
主要方法:
- 使用国家登记册进行的以人口为基础的回顾性队列研究.
- 包括1至17岁的新加坡儿童,他们有实验室确认的登革热或SARS-CoV-2.
- 考克斯回归分析用于评估心血管,神经,胃肠道,自身免疫和呼吸道并发症的风险,感染后31-300天.
主要成果:
- 其中包括6,452例登革热病例和260,749例COVID-19病例.
- 登革热感染与后急性胃肠连续症的风险增加有关,包括尾炎 (aHR,3.50).
- 与未接种疫苗的COVID-19相比,登革热感染的总体风险 (aHR,0.42) 和呼吸系统后续风险 (aHR,0.17) 较低.
结论:
- 与COVID-19相比,儿童在登革热感染后经历了急性后并发症的整体风险较低.
- 在登革热感染31-300天后,尾炎的风险比SARS-CoV-2的风险更高.
- 公共卫生策略必须考虑儿童登革热和COVID-19的慢性后感染后续.
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