功能性腹回的心房患者的电气重塑和低压区域:一个多中心评估
Li-Jun Zeng1, Xiao-Bo Pu2, Xin Wei2
1Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, 610041 Chengdu, Sichuan, China.
Reviews in cardiovascular medicine
|March 31, 2025
概括
显著的心房纤维化在心房动和心肌吐患者中很常见,这可能会限制导管切除在减少心房大小和心律失常方面的有效性. 为了找到最佳的治疗策略,需要进一步的研究.
科学领域:
- 心脏病学 心脏病学
- 电子生理学 电子生理学
- 心脏成像 - - 心脏成像
背景情况:
- 心房纤维化是心房动 (AF) 和功能性心肌吐 (MR) 的关键基质.
- 准确识别心房纤维化对于指导这些疾病的治疗干预至关重要.
研究的目的:
- 为了调查心房纤维化在患者中患有心房纤维化的患病率,这些患者接受了持续性AF的导管切除,并具有中度至重度的MR.
- 评估心房纤维化对临床结果的影响,包括心房尺寸缩小和心律失常后心律失常复发.
主要方法:
- 分析了75名患有持续性AF和中度至重度MR,接受了导管切除的患者的临床数据.
- 在切除过程中使用电压映射来分类心房纤维化程度.
- 患者的结局在废除后1年被评估.
主要成果:
- 在45.3%的患者中发现了显著的心房纤维化,这与更高的充血性心力衰竭和心房扩大率有关.
- 虽然整体队列显示左心房大小减少和MR后移除,显著的纤维化组有较高的心律失常复发率 (55.9%对22.0%) 和心房大小没有显著变化.
- 在70.7%的患者中,MR显著减少.
结论:
- 相当一部分心房功能性MR和AF患者表现出显著的心房纤维化.
- 显著的纤维化可能会阻碍心房大小的缩小,并在导管切除后增加心律失常的复发.
- 需要新的治疗策略,以有效地管理心房大小和心律失常在这个患者小组.
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