在大血管封闭中估计低 perfused 组织体积:伪连续动脉旋转标记与动态易感度对比输液加权成像对比
Chenxi Zhao1, Chen Cao2, Lei Ren3,4
1Department of Radiology, The First Central Clinical School, Tianjin Medical University, Tianjin, China.
Quantitative imaging in medicine and surgery
|March 31, 2025
概括
伪连续动脉旋转标记 (pCASL) 显示与动态敏感度对比透成像 (DSC-PWI) 的一致性,用于估计大血管封闭 (LVOs) 中的低透组织. 这种动脉旋转标记方法,当对动脉传输时间进行校正时,适用于临床选择患者进行内血管血栓切除术.
科学领域:
- 神经成像是一种神经成像.
- 血管神经学 血管神经学
- 医学成像技术 医学成像技术
背景情况:
- 目前在急性大血管封闭 (LVOs) 中进行内血管血栓切除术 (EVT) 的选择依赖于动态敏感度对比透成像 (DSC-PWI) 或CT perfusion.
- 评估低透组织 (HPT) 容量对于EVT患者的选择至关重要.
- 研究替代性输液成像技术对于改善患者选择至关重要.
研究的目的:
- 为了评估在前面的LVOs中纠正/未纠正的多延迟伪连续动脉旋转标记 (pCASL) 和DSC-PWI之间的低透气组织 (HPT) 体积估计的一致性.
- 评估pCASL在选择急性LVOs患者进行EVT的诊断性能.
主要方法:
- 对108名急性和90名症状慢性LVO患者进行了回顾性研究.
- 通过使用DSC-PWI和多延时pCASL估计的HPT数量的比较,使用类内相关系数 (ICC).
- 接收器操作特征 (ROC) 分析,以评估用于EVT选择的诊断性能.
主要成果:
- 经过校正的多延迟pCASL显示,在急性 (ICC=0.742) 和慢性 (ICC=0.617) LVOs中,HPT体积估计与DSC-PWI有很大一致性.
- 通过pCASL获得的HPT体积与不同值的DSC-PWI体积相比较.
- 经过动脉传输时间 (ATT) 校正的pCASL在选择患者进行EVT方面表现良好 (AUC=0.804).
结论:
- 在LVO患者中,与DSC-PWI相比,校正的多延迟pCASL提供了一致的HPT体积估计.
- 通过ATT调整的多延迟pCASL是一种可行且可能更适用的方法,用于在EVT患者选择中进行常规临床使用.
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