在墨西哥成年人中确定胰岛素抵抗截止值:百分比分布与接收器操作特征曲线分析
Maria Fernanda Decaro-Fragoso1, Teresa Estrada-Garcia1, Catalina Lopez-Saucedo1
1Department of Molecular Biomedicine, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, MEX.
Cureus
|March 31, 2025
概括
确定最佳的恒温模式评估胰岛素抵抗 (HOMA-IR) 截止值对于识别代谢综合征风险至关重要. 基于百分点的方法有效地使得早期检测胰岛素抵抗,帮助预防性干预.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 临床诊断 临床诊断 临床诊断
背景情况:
- 胰岛素抵抗 (IR) 是代谢综合征 (MetS),2型糖尿病和心血管疾病的关键因素.
- 胰岛素抵抗的恒温模型评估 (HOMA-IR) 是估计IR的常用工具.
- 风险识别的最佳HOMA-IR截止值缺乏共识.
研究的目的:
- 为了比较百分点分布和接收器运行特征 (ROC) 曲线分析,以确定HOMA-IR切线.
- 在墨西哥城人口中建立最佳的HOMA-IR切割值.
- 评估用于早期IR检测的不同方法的有效性.
主要方法:
- 在墨西哥城对765名成年人的横截面研究.
- 使用健康基准组的第75百分位和MetS组的ROC曲线分析对HOMA-IR值进行比较.
- 使用尤登指数确定最佳切断线.
主要成果:
- 第75和第90个HOMA-IR百分位分别为2.72和3.71.
- ROC曲线分析为MetS诊断产生了比百分位数方法更高的切断值.
- 基于百分点的方法有助于更早地识别有风险的个体,包括那些没有明显的MetS的人.
结论:
- 对于HOMA-IR截止值的确定方法产生了可变的结果,这强调了对人口特定值的需求.
- 基于百分点的方法对于早期IR检测和临床前干预是有效的.
- 基于百分比的切割值为增强风险评估和临床决策提供了一个实用的工具.
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