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性别和代谢因素与T2DM中的甲状腺结节的关联:一项回顾性研究
Xi Yuan1, Xin Wang1, Xinwen Yu1
1Department of Endocrinology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
PeerJ
|March 31, 2025
概括
甲状腺结节 (TNs) 在患有2型糖尿病 (T2DM) 的女性中更常见. 肥胖和高尿血症在这些妇女中显著增加了TNs的风险,突出了降低风险的可修改因素.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 甲状腺学 甲状腺学
背景情况:
- 甲状腺结节 (TN) 发生率的性别差异已知,但在2型糖尿病 (T2DM) 中的特定关联需要进一步调查.
- 了解这些差异对于针对性地评估和管理T2DM患者的风险至关重要.
研究的目的:
- 调查T2DM男性和女性患者中人类参数和TN之间的关联.
- 鉴定T2DM中TNs的特定风险因素,考虑基于性别的差异.
主要方法:
- 一项涉及747名T2DM患者的横截面研究.
- 数据收集包括临床检查,甲状腺超声波,实验室测试,人体测量和身体成分分析.
- 用多变量逻辑回归和名录发展来分析与TNS相关的因素.
主要成果:
- 总体TNs发生率为36.95%,女性 (52.75%) 显著高于男性 (27.85%).
- 年龄与两性TN风险都有积极的相关性.
- 肥胖和高尿路血症与女性的TN风险有显著的关联,但与男性没有关联. 在女性T2DM患者中开发了一种TN风险的nomogram.
结论:
- 与男性相比,T2DM女性的TNs更为频繁.
- 肥胖和高尿血是T2DM女性中TN的关键可修改的风险因素.
- 针对这些代谢因素可能有助于降低女性T2DM患者的TN风险.
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