阴道微生物群,症状和局部免疫相关性在使用持续丸激素治疗的跨男性个体中
Bern Monari1, Hannah Wilcox2, Priscilla Haywood1
1Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
bioRxiv : the preprint server for biology
|March 31, 2025
概括
接受丸激素治疗的跨男性个体通常具有多样化的阴道微生物群,而不是最佳的乳杆菌主导类型. 令人惊的是,这些人中的乳酸菌占主导地位与不良症状和炎症有关.
科学领域:
- 生殖健康 生殖健康
- 微生物组研究 微生物组研究
- 内分泌学 在内分泌学.
背景情况:
- 变性男性使用性别肯定性丸激素治疗.
- 在治疗期间报告了生殖器症状.
- 阴道微生物群影响生殖健康;乳酸菌在阴道女性中占主导地位最佳.
研究的目的:
- 描述跨男性个体的阴道微生物群.
- 评估微生物群,炎症 (SMI) 和症状之间的联系.
- 确定在丸激素治疗期间,乳酸菌的优势是否是最佳的.
主要方法:
- 在TransBiota研究中,纳入了变性男性个体.
- 在三个星期内分析了阴道微生物群,局部炎症 (SMI) 的可溶性媒介和症状.
- 确定了社区国家类型 (CST).
主要成果:
- 不到10%的参与者有乳酸菌占主导地位的微生物群.
- 大多数都表现出多样化,缺乏乳酸菌的微生物群.
- 确定了11种跨男性性CST (tmCST);乳杆菌主导的tmCST与异常的气味和升高的IL-1α有关.
结论:
- 对于接受丸激素治疗的跨男性个体来说,乳酸菌的优势可能不是最佳的.
- 目前的临床管理可能需要调整.
- 需要进一步的研究,以了解这种人群的最佳阴道微生物群状态.
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