在寻找食物的过程中,核 accumbens 中的多巴胺和动态
Sophia J Weber1, Gillian S Driscoll1, Madelyn M Beutler1
1Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239.
bioRxiv : the preprint server for biology
|March 31, 2025
概括
这项研究揭示了核如何聚集核心活动和多巴胺信号变化在寻找食物和灭绝期间. 同时录制显示在寻求奖励的行为和恢复期间明显的神经模式.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 成研究 研究成研究
背景情况:
- 灭绝-恢复范式对于理解寻求回报的行为至关重要,特别是对于食物和药物.
- 核在激发动机行为中起着关键作用,之前的研究将其活动和多巴胺信号与减少寻找食物联系起来.
- 之前的研究强调了核在激发行为中的作用,但在灭绝-恢复过程中缺乏同时记录谷氨基基输入和多巴胺基调.
研究的目的:
- 在食物奖励灭绝-恢复任务期间,调查核中谷氨酸输入和多巴胺 (DA) 基调之间的关系.
- 在核中同时测量神经元活动 (通过指标) 和多巴胺信号 (通过DA生物传感器).
- 通过自我管理培训,灭绝和恢复阶段来表征DA过渡物和信号的变化.
主要方法:
- 在动物中利用经典的灭绝-恢复范式与食物奖励.
- 在核中采用传感器多重复合,将一种遗传编码的指标用于谷氨酸代谢输入代理和一个红移的DA生物传感器结合起来.
- 在自我管理,灭绝会议和恢复测试期间记录了神经元和多巴胺活动,使用引导分析来检测反应.
主要成果:
- 在自我管理培训期间观察到大小和时间模式各异的DA过渡.
- 检测到信号的减少时间锁定到杆压力,这与训练加剧.
- 在灭绝过程中注意到DA和活性降低,在后面的会议中没有基线偏移;反应出现在暗示前置恢复过程中,而DA反应是针对颗粒+暗示前置恢复的.
结论:
- 强化了核 accumbens 核心活动和多巴胺在恢复寻找食物行为的参与.
- 在灭绝恢复任务期间,在核 accumbens 中核中首次同时记录谷氨酸输入和多巴胺基调.
- 表明信号传递和多巴胺在奖励寻求和恢复的不同阶段有不同的作用,特别是在响应特定的线索时.
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