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Updated: May 17, 2025

Analysis of LINE-1 Retrotransposition at the Single Nucleus Level
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Analysis of LINE-1 Retrotransposition at the Single Nucleus Level

Published on: April 23, 2016

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反转移子的直接细胞间传播

Maya Voichek1, Andreas Bernhard1, Maria Novatchkova1

  • 1Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna BioCenter (VBC); Dr. Bohr-Gasse 3, 1030 Vienna, Austria.

bioRxiv : the preprint server for biology
|March 31, 2025
PubMed
概括

可移植的元素现在可以感染Drosophila体细胞的生殖系,使用一种新型蛋白质 (sORF2) 而不是典型的病毒包膜蛋白进行传播. 这一发现揭示了遗传元素传播和进化的新机制.

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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