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Updated: May 17, 2025

Inhibitory Synapse Formation in a Co-culture Model Incorporating GABAergic Medium Spiny Neurons and HEK293 Cells Stably Expressing GABAA Receptors
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在GABAA受体β2亚单元中的误解变异会破坏受体生物发生,并导致功能丧失

Xi Chen1, Ya-Juan Wang1, Ting-Wei Mu1

  • 1Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.

bioRxiv : the preprint server for biology
|March 31, 2025
PubMed
概括

GABRB2基因中的四种相关变异通过破坏蛋白质平衡来损害GABAAR功能. 这些变异导致β2亚单元的错误折叠和降解,影响受体组合和表面表达,这对神经功能至关重要.

关键词:
在GABAA受体中,GABAA受体是在GABRB2中,GABRB2是指GABRB2.组装的组装组装的组装.降解降解降解降解降解.细胞内膜网膜的内oplasmic网膜.是一种.折叠 折叠 折叠 折叠错误的意义 变体 变体蛋白质稳定症是一种蛋白质稳定症.走私和贩运的人口贩运

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