脂肪味道反应,但不是饮食中的脂肪摄入量,在无Adipor1小鼠中受到影响
Fangjun Lin1,2, Timothy A Gilbertson2
1Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32827, USA.
bioRxiv : the preprint server for biology
|March 31, 2025
概括
亚迪波涅丁受体1 (AdipoR1) 在脂肪味觉和体重调节方面发挥着性别特异性的作用. 阿迪波R1淘汰赛小鼠对脂肪酸的反应发生了变化,影响了味道和体重增加,特别是在雌性中.
科学领域:
- 代谢和内分泌学
- 神经科学是一个神经科学.
- 感官生物学 感官生物学
背景情况:
- 通过AdipoR1传递的阿迪波内克信号增强了味觉细胞中的脂肪酸反应.
- 阿迪波R1在脂肪味觉和饮食脂肪摄入中的作用仍然在很大程度上未被描述.
研究的目的:
- 研究AdiporoR1基因淘汰对脂肪细胞,神经和行为反应的影响.
- 评估阿迪波R1缺乏对小鼠饮食脂肪摄入量和体重调节的影响.
主要方法:
- 使用全球AdipOR1淘汰赛 (Adipor1-/-) 和野生型 (WT) 鼠标进行比较分析.
- 通过成像,对林诺基酸 (LA) 的性别特异性细胞反应进行了评估.
- 评估对脂肪的行为反应,使用简短的口味测试,两瓶偏好和有条件的口味厌恶测试.
- 在高脂肪饮食养研究中监测饮食脂肪摄入量和体重变化.
主要成果:
- 在Adipor1-/-小鼠中观察到LA诱导的味觉细胞中反应的性别特异性变化.
- 脂肪1-/-小鼠最初表现出对脂肪的行为反应丧失,在脂肪暴露后,男性的行为反应部分恢复.
- 肥胖1-/- 雌性对LA的偏好降低,在厌恶试验中避免减少,在高脂肪饮食中体重增加较大.
- 在Adipor1-/-和WT小鼠之间,没有发现味觉神经反应或整体食脂肪摄入量的显著差异.
结论:
- 在调节脂肪味觉方面,AdipoR1信号传递调解了性别特异性的作用.
- 缺乏AdipoR1会影响体重调节,主要是通过能量消耗,而不是直接改变饮食脂肪摄入量.
- 这些发现凸显了AdipoR1在将味道信号与代谢平衡整合中的关键作用.
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