杜洛特格拉维尔在中度重症COVID-19患者中的有效性:一个单中心,随机,双盲,安慰剂控制的试验
Hamideh Abbaspour Kasgari1, Siavash Moradi2, Ahmad Alikhani3
1Department of Clinical Pharmacy, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
BioImpacts : BI
|March 31, 2025
概括
作为HIV-1整合酶抑制剂的多卢特格拉维尔,并没有改善中度COVID-19的住院患者的临床康复. 需要进一步的大型随机试验来确认这些研究结果用于COVID-19治疗.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 临床药理学 临床药理学
背景情况:
- 药物重新定位为治疗COVID-19等新出现的传染病提供了一种具有成本效益和节省时间的方法.
- 作为HIV-1整合酶抑制剂的多卢特格拉维尔 (Dolutegravir) 被研究其对中度COVID-19的潜在治疗效果.
研究的目的:
- 评估杜洛特格拉维尔在中度COVID-19的住院成人患者中改善临床康复的疗效.
- 评估dolutegravir是否在标准治疗中添加时,在COVID-19患者中比安慰剂更有好处.
主要方法:
- 一项随机,双盲,安慰剂对照试验与93名被诊断为中度COVID-19的成年患者进行.
- 患者每天接受50毫克杜洛特格拉维尔或安慰剂,持续7天,同时接受包括雷梅西维尔在内的标准治疗.
- 主要终点是研究开始10天后评估的患者康复.
主要成果:
- 杜洛特格拉维尔和安慰剂组之间在呼吸支频率,呼吸速率或氧气和方面没有发现显著差异.
- 该研究包括了46名多卢特格拉维尔手臂的患者和47名安慰剂手臂的患者.
结论:
- 杜洛特格拉维尔治疗与中度COVID-19的住院成年患者的临床康复改善无关.
- 需要进行更大规模的随机试验,以确定杜洛特格拉维尔在COVID-19治疗中的有效性.
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