Ananas comosus纳米乳液对炎症阶段创伤性的作用
Juni Handajani1, Widjijono2, Heni Susilowati1
1Department of Oral Biology, Faculty of Dentistry, Universitas Gadjah Mada, Indonesia.
Journal of Taibah University Medical Sciences
|March 31, 2025
概括
提取物纳米乳液通过减少伤口大小,在老鼠中加速创伤性的愈合. 这种自然治疗增加了中性粒细胞和COX-2表达,这是炎症阶段的关键指标,表明增强了愈合机制.
科学领域:
- 口服药是一种口服药.
- 伤口愈合研究研究研究
- 自然产品药理学 自然产品药理学
背景情况:
- 炎症阶段对于伤口愈合至关重要,涉及复杂的细胞和分子事件.
- 口腔粘膜的创伤性会损害生活质量.
- 天然成分,如含有素的果提取物,显示出口腔伤口治疗的潜力.
研究的目的:
- 为了评估 (Ananas comosus (L.) Merr) 提取物纳米乳液在治疗创伤性口腔的炎症阶段的疗效.
- 研究提取物对伤口愈合中的关键炎症标记物的影响.
主要方法:
- 在24只Wistar老鼠的口腔粘膜上创建了一个创伤性的模型.
- 鼠每天接受四天的治疗,使用提取物纳米乳液或阳性对照 (Aloclair Plus Gel®).
- 组织学分析评估了中性粒细胞计数和COX-2表达在诱导后的0,1,2和3天.
主要成果:
- 与对照组相比,提取物纳米乳液显著减少了伤口直径.
- 在提取物组中观察到中性粒细胞数量和COX-2表达的显著增加.
- 中性粒细胞数量在第一天达到峰值,而COX-2表达在第三天达到峰值.
结论:
- 茎提取物纳米乳液显示有可能加速创伤性口腔的愈合.
- 观察到的中性粒细胞和COX-2表达的增加表明增强的炎症反应有助于更快的愈合.
- 这项研究支持使用提取物作为口腔伤口管理的天然治疗剂.
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